{"id":18358,"date":"2026-04-23T10:43:43","date_gmt":"2026-04-23T10:43:43","guid":{"rendered":"https:\/\/next-fertilitynordic.com\/?p=18358"},"modified":"2026-04-23T10:43:44","modified_gmt":"2026-04-23T10:43:44","slug":"the-clinical-relevance-of-pgta","status":"publish","type":"post","link":"https:\/\/next-fertilitynordic.com\/en\/the-clinical-relevance-of-pgta\/","title":{"rendered":"The clinical relevance of PGTA"},"content":{"rendered":"\n

We\u2019re in the era that Preimplantation genetic testing<\/a>(in short PGT) is becoming more relevant in modern fertility treatment. Society is definitely aging, which means women are starting their families later.<\/p>\n\n\n\n

On average, women are also having less children. There is a clear decline in birth rate in Europe and Estonia is no different. In 2024 the average age for a women to give birth in Estonia was 31 years old. Women had on average 1.2 children and there were fewer than 10,000 births in total. Believe it or not, at age 35 reproductively speaking women are considered of advanced maternal age. Our biology is catching up to us.<\/p>\n\n\n\n

Circumstances when PGTM is relevant<\/h2>\n\n\n\n

In comparison to PGT-A,<\/a> PGT for structural rearrangements (PGT-SR) and for monogenic diseases (PGT-M) is only applicable to specific and small patient population. <\/p>\n\n\n\n

In Estonia, the deafness gene is a common example because of the small population. If a couple finds that they are both carriers of the same disease, it means their child has a significant risk of inheriting the disease. A simple blood test identifies carriers, and if both partners are carriers, genetic testing avoids passing the genetic trait down to offspring.<\/p>\n\n\n

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Patients\u2019 expectations are important<\/h2>\n\n\n\n

Ideally patients should come into the cycle feeling informed about their realistic chances based on their medical history and age.<\/p>\n\n\n\n

Some patients have already had a miscarriage due to a genetic problem, so they’re expecting some abnormal embryos. When those results come back, it can give some clarity to why a previous pregnancy may not have progressed.<\/p>\n\n\n\n

Even when results show abnormal embryos, there’s a positive side: patients don’t waste time on multiple failed transfers. This matters a lot after age 39, when time is limited. Getting PGT results means they can start their next cycle sooner, which can really help.<\/p>\n\n\n\n

After a few rounds of PGT, we get a clearer picture of what’s happening. It helps patients and doctors understand the real situation and make better decisions about what to do next.<\/p>\n\n\n\n

2025 recap<\/h2>\n\n\n\n